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  • The Science Behind Zetia: a Deeper Dive into Its Mechanism

    The Science Behind Zetia: a Miracle Cholesterol Medication


    Zetia, a revolutionary cholesterol medication, has been hailed as a game-changer in the realm of cardiovascular health. This innovative drug works by targeting a unique mechanism that sets it apart from traditional cholesterol-lowering treatments. Unlike statins, which focus on reducing the production of cholesterol, Zetia takes a different approach by inhibiting the absorption of cholesterol in the body.

    The key to Zetia's success lies in its active ingredient, ezetimibe, which effectively blocks the NPC1L1 protein responsible for transporting cholesterol from the intestines into the bloodstream. By preventing this crucial step, Zetia helps to lower overall cholesterol levels, making it a valuable tool in the fight against heart disease and other cardiovascular complications.

    Zetia's Mechanism Inhibiting Cholesterol Absorption
    Zetia's active ingredient, ezetimibe, targets the NPC1L1 protein By blocking the absorption of cholesterol from the intestines, Zetia helps to lower overall cholesterol levels



    Zetia's Mechanism: Inhibiting Cholesterol Absorption for Better Health



    Zetia's unique mechanism of action lies in its ability to inhibit the absorption of cholesterol from the diet. This innovative approach to cholesterol management sets Zetia apart from traditional medications. By targeting the specific protein responsible for cholesterol transport in the intestines, Zetia effectively blocks the uptake of cholesterol, leading to a reduction in overall blood cholesterol levels. This targeted mechanism allows Zetia to work in harmony with the body's natural processes, providing a more holistic solution to the challenge of maintaining healthy cholesterol. The science behind Zetia's effectiveness has paved the way for a new era in cholesterol management, offering patients a targeted and efficient way to improve their cardiovascular health.



    Exploring the Intricate Workings of Zetia's Active Ingredient


    Zetia's active ingredient, ezetimibe, is a marvel of modern pharmaceutical chemistry. This unique compound has the remarkable ability to disrupt the absorption of cholesterol in the small intestine, effectively lowering the amount of cholesterol that enters the bloodstream. By targeting a specific protein responsible for cholesterol uptake, ezetimibe elegantly prevents this vital nutrient from being over-consumed, leading to healthier cholesterol levels. The intricacies of ezetimibe's mechanism of action continue to captivate researchers, as they unravel the delicate balance of cholesterol regulation and the role this innovative drug plays in promoting overall cardiovascular well-being.



    Zetia's Unique Approach to Cholesterol Management: a Deeper Dive



    Zetia's unique approach to cholesterol management delves deeper into the intricate mechanisms that set it apart from traditional cholesterol-lowering medications. Unlike statins, which primarily target the liver, Zetia focuses on inhibiting the absorption of cholesterol in the intestines, offering a targeted and complementary strategy for managing high cholesterol levels. This innovative approach provides patients with an alternative option that can effectively work in tandem with statin therapy, allowing for a more comprehensive and personalized approach to cholesterol management.



    Understanding the Science Behind Zetia's Therapeutic Benefits


    Zetia's unique mechanism of action unlocks its impressive therapeutic benefits. By selectively inhibiting the absorption of dietary cholesterol, Zetia effectively lowers LDL-cholesterol levels in the body. This targeted approach addresses the root cause of high cholesterol, leading to improved cardiovascular health and reduced risk of heart disease. Extensive clinical trials have demonstrated Zetia's ability to significantly reduce LDL-cholesterol and deliver positive outcomes for patients struggling with hypercholesterolemia. The science behind Zetia's success lies in its innovative targeting of the cholesterol absorption process, offering a novel and effective solution for managing this common health concern.

    Zetia's Therapeutic Benefits Impact
    Lowers LDL-cholesterol levels Improved cardiovascular health
    Targets cholesterol absorption Addresses root cause of high cholesterol
    Demonstrated efficacy in clinical trials Positive outcomes for patients with hypercholesterolemia



    Unveiling the Groundbreaking Discoveries in Zetia's Development


    The journey to unravel the groundbreaking discoveries behind Zetia's development was paved with meticulous research, serendipitous insights, and a relentless pursuit of understanding the intricate mechanisms of cholesterol metabolism. Researchers delved deep into the complex interplay between dietary cholesterol, intestinal absorption, and the body's regulatory pathways, unearthing pivotal findings that would ultimately shape the creation of this revolutionary medication.

    Through extensive laboratory experiments and clinical trials, the scientific team behind Zetia uncovered the critical role played by the Niemann-Pick C1-Like 1 (NPC1L1) protein in facilitating cholesterol absorption within the intestines. This pivotal discovery provided the foundation for the development of Zetia, a drug that selectively targets and inhibits the NPC1L1 protein, effectively reducing the amount of cholesterol absorbed into the body.

    The groundbreaking nature of Zetia's development lies in its unique approach to cholesterol management, diverging from traditional statin-based therapies. By addressing the root cause of elevated cholesterol levels at the point of intestinal absorption, Zetia offers a novel and effective solution for individuals struggling with high cholesterol, showcasing the power of scientific innovation to transform lives.

    Underpinning the success of Zetia is the dedication and perseverance of the researchers who meticulously unraveled the intricate mechanisms governing cholesterol homeostasis. Their relentless pursuit of understanding the science behind this critical physiological process has paved the way for the development of a medication that has since transformed the landscape of cholesterol management, benefiting countless individuals in their journey towards better cardiovascular health.





ARIZONA PSYCHIATRIC SOCIETY 2024-2025 EXECUTIVE Board

President: Nicholas Ahrendt, MD President-Elect: Margaret Balfour, MD, PhDVice President: Brenner Freeman, MDTreasurer: Robert Rymowicz, DOSecretary: Chiranjir "Ravi" Narine, MD Co Resident-Fellow Member Representatives: Nehal Samra, MD Creighton Matthew Mitchell, MD UA-PhoenixGagan Singh, MD UA-Tucson
APA Assembly Representatives: Jason Curry, DO (serves term concluding 2024) Jasleen Chhatwal, MBBS, MD (two-year term concluding 2024)Payam Sadr, MD (one-year term concluding 2024) Past President Gagandeep Singh, MD, DFAPA Stephen "Larry" Mecham, DO The Society thanks these members for their leadership.

Celebrating our members

Chase was born and raised in Phoenix, AZ, and attended ASU for a bachelor’s degree in business then attended KCUMB for medical school in Kansas City. He was excited to return home to AZ when he found out he'd been matched with UACOM – Phoenix for his psychiatry residency.
He was first drawn to the field of psychiatry during his years in medical school as he found the psychiatric subject matter and the patients to be the most engaging and interesting of all his studies. He quickly came to realize that without a healthy mind, one is unable to thoroughly experience life constructive way. He wanted to be the person to help those struggling with mental illness as he found these cases and experiences to be the most rewarding in medicine.
Dr. Crookham said he has been lucky enough to have been matched at a great psychiatric residency program where he gets to learn from great mentors and colleagues every day. He believes his passion for psychiatry along with the relationships he's developed with his colleagues and mentors will carry him to be a lifelong learner and devoted psychiatrist for his future patients.
Meghan is a graduate of Lincoln Memorial University, DeBusk College of Osteopathic Medicine.
She received her Bachelor of Arts from the University of Denver in French and Biology with a concentration in Cognitive Neuroscience.
She is currently a chief resident at UACOM-Tucson in her final year of psychiatry training and will be starting a fellowship in Addiction Medicine at the University of Arizona, Tucson in July.
Her professional interests include physician mental health, adult consult liaison and addiction psychiatry.
In her personal time, she enjoys home design projects, spending time with family, learning about plants, and exploring new places.
Dr. Hintze is currently honeymooning in Japan! Congratulations!!
Danny is originally from Phoenix. Graduated from Brophy, ASU, and UA Tucson Medical School. His background is in economics, philosophy of science, and rational decision-making.
He was drawn to psychiatry because of the conceptual complexity and the profound impact even relatively simple pharmaceutical, medical, and psychotherapeutic interventions can have to empower patients and their families.
As a mentor, he wanted to recognize the many people within the Arizona Medical Community, particularly at UA Tucson, Valleywise, and within organized medicine who have worked to protect and promote medicine as a joyful, compassionate, and healing experience for patients and for all of us who help care for them.

ARIZONA PSYCHIATRIC SOCIETY past presidents

Otto L. Bendheim, M.D. 1960-1961Warren S. Williams, M.D. 1961-1963T. Richard Gregory, M.D. 1963-1964Boris Zemsky, M.D. 1964-1965 Hal J. Breen, M.D. 1965-1966Joseph M. Green, M.D. 1966-1967Irene M. Josselyn, M.D. 1967-1968Hubert R. Estes, M.D. 1968-1969Richard H. Bruner, M.D. 1969-1970Thomas F. Kruchek, M.D. 1970-1971David S. Burgoyne Sr., M.D. 1971-1972Marshall W. Jones, M.D. 1972-1973Harold D. Haeussler, M.D. 1973-1974William B. Haeussler, M.D. 1974-1975Edward S. Gelardin, M.D. 1975-1976Hugo L. Cozzi, M.D. 1976-1977Robert F. Meyer, M.D. 1977-1978James E. Campbell, M.D. 1978-1979Stuart M. Gould, M.D. 1979-1980Elliot M. Heiman, M.D. 1980-1981Stephen V. Shanfield, M.D. 1981-1982Jerry A. Biggs, M.D. 1982-1983Robert C. Shapiro, M.D. 1983-1984Dennis C. Westin, M.D. 1984-1985John H. Jarvis, M.D. 1985-1986James G. Hill, M.D. 1986-1987Robert P. Bevan, M.D. 1987-1988Eugene J. Kinder, M.D. 1988-1989 James M. Campbell, M.D. 1989-1990David S. Burgoyne II, M.D. 1990-1991
Stuart W. Hollingsworth, M.D. 1991-1992Kevin J. Leehey, M.D. 1992-1993Stephen S. Brockway, M.D. 1993-1994Michael H. Stumpf, M.D. 1994-1995Lauro Amezcua-Patino, M.D. 1995-1996David S. Burgoyne II, M.D. 1997-1998Glenn Lippman, M.D. 1998-1999Lisa Jones, M.D. 1999-2000David J. Coons, M.D. 2000-2001James M. Campbell, M.D. 2001-2002Bradley Johnson, M.D. 2002-2003David W. Leicken, M.D. 2003-2004Thomas N. Crumbley, M.D. 2004-2006Jeffrey L. Schwimmer, M.D., M.P.H. 2006-2007Stephen O. Morris, M.D. 2007-2008Jack L. Potts, M.D. 2008-2009Elizabeth A. Kohlhepp, M.D. 2009-2010Michael E. Brennan, M.D. 2010-2011Gretchen Alexander, M.D. 2011-2012Tariq M. Ghafoor, M.D. 2012-2013Joanna K. Kowalik, M.D., M.P.H., 2013-2014Payam M. Sadr, M.D., 2014-2015Roland Segal, M.D., 2015-2016Gurjot Marwah, M.D., 2016-2017Aaron Wilson, M.D., 2017-2018Mona Amini, M.D., 2018-2019 Don J. Fowls, M.D., 2019-2020 Jasleen Chhatwal, M.B.B.S., M.D., 2020-2022 Stephen Larry Mecham, DO, 2022-2023 Gagandeep Singh, MD, DFAPA 2023-2024
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